Purine nucleotides
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 100mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Medchemexpress LLC Adenosine 5'-triphosphate | 56-65-5 | 95.7% | 507.18 g/mol | C10H16N5O13P3 | 10 MG
Adenosine 5'-triphosphate (ATP) standard supplied as a 10 mg solid for analytical and research use. It is intended as a calibration and reference material for quantitation of ATP in biochemical assays, metabolic studies, and signaling research.
- Analytical reference standard for ATP quantitation.
- High purity: 95.7%.
- White to off-white solid suitable for dissolution in aqueous buffers.
- Useful for assay calibration, method development, and quality control.
- Includes CAS number 56-65-5 for clear substance identification.
Medchemexpress LLC Adenosine 5'-diphosphoribose | 20762-30-5 | 98.2% | 559.32 g/mol | C15H23N5O14P2 | 5 MG
Adenosine 5'-diphosphoribose is an endogenous nucleotide (ADP ribose) consisting of an adenine base linked to a ribose and two phosphate groups. Supplied as a research-grade solid, it is used in biochemical and cellular assays to investigate ADP-ribosylation signaling, DNA damage response pathways, and calcium-permeable TRPM2 channel activation. The material is provided in assay-friendly quantities with supporting documentation for safe handling.
Medchemexpress LLC Adenosine 5'-diphosphoribose | 20762-30-5 | 559.32 | C15H23N5O14P2 | 50 MG
Adenosine 5'-diphosphoribose (ADP ribose) is a nucleotide metabolite supplied as a research reagent for biochemical and analytical studies. It is used to investigate NAD+ metabolism, TRPM2 channel activation, and ADP-ribosylation pathways. Intended for research use only.
- Nucleotide metabolite for biochemical and analytical assays.
- Molecular formula C15H23N5O14P2; molecular weight 559.32.
- Used in studies of NAD+ metabolism, TRPM2 activation, and ADP-ribosylation.
- Manufacturer datasheet lists pack sizes 1 mg, 5 mg, and 10 mg.
Medchemexpress LLC Adenosine 5'-diphosphoribose | 20762-30-5 | 98.2% | 559.32 g/mol | C15H23N5O14P2 | 100 MG
Adenosine 5'-diphosphoribose is an endogenous adenosine diphosphate-ribose provided as a light yellow to yellow powder for laboratory research. It is used as a biochemical reagent and reference standard in studies of ADP-ribosylation, nucleotide signaling, and enzymology, with specified storage and solubility guidelines for reliable handling.
- High purity suitable for analytical and biochemical assays.
- Stable as a powder when stored at -20°C for long-term storage.
- Soluble in water; may require sonication for complete dissolution.
- Available in multiple pack sizes, including 100 mg for routine experiments.
- Applicable to enzymology, ADP-ribosylation, and nucleotide signaling studies.
Sigma Aldrich Fine Chemicals Biosciences ATP Bioluminescence Kit Su
Adenosine triphosphate (ATP) is a key molecule that stores energy within cells and is considered as the universal energy currency for all living organisms. ATP has been used as a marker of viability as living cells have high ATP content whereas dead cells lose their ability to produce ATP. ATP levels are therefore proportional to the amount of living cells in a sample. The ATP Bioluminescence Kit provides a simple and quick assay to quantify ATP and also to measure cell viability based on ATP content. This assay is less prone to artifacts than other viability assay methods. Intracellular ATP is released by permeabilization SOLUTIONon and measured using a bioluminescence assay owing to the ability of luciferase to produce light in the presence of its substrate D-luciferin and ATP. The kit has the following linear detection range0 - 60 000 cells (tested on TF-1 cells)1nM-10muM ATP
Sigma Aldrich Fine Chemicals Biosciences Guanosine 5 betagama imi100MG
Guanosine 5prime-[beta gamma-imido]triphosphate (GMP-PNP Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding including GTP-activation GTP-inhibition GTP transport GTP hydrolysis and GTP structure stabilization. Since a cycle of GTP binding hydrolysis and release is required for the initiation of protein translocation across the endoplasmic reticulum guanosine 5prime-[beta gamma-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling protein synthesis and other metabolic processes.
Medchemexpress LLC Cytarabine triphosph 25mg | 1179343-17-9 | 25 MG
Cytarabine triphosphate trisodium is the trisodium salt of cytarabine triphosphate and is used as a research reagent to study DNA synthesis inhibition and nucleoside metabolism.
- Trisodium salt form supplied as a solution.
- Pack size 25 mg, prepared as 100 mM x 500 μL in water for the 25 mg vial.
- Molecular formula C9H13N3Na3O14P3 and molecular weight 549.10 g/mol.
- Purity approximately 96.8%.
- Storage: solution at -20°C; prepared stock solution stability: -80°C for 6 months, -20°C for 1 month.
- Used as the active metabolite Ara-CTP in biochemical and cell-based assays targeting DNA synthesis.
TARGETMOL CHEMICALS INC Research Chemical 500mg
Also available in and bulk. Please contact Fisher for quotes. Cytidine-5'-triphosphate disodium (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. Cytidine-5'-triphosphate disodium is used in the synthesis of RNA by RNA polymerases. In the formation of phosphatidylcholine (PC), Cytidine-5'-triphosphate disodium reacts with phosphocholine, via CTP,phosphocholine cytidylyltransferases, to produce CDP-choline and diphosphate. purity: 97%
Medchemexpress LLC Adenosine deaminase 250U | 9026-93-1 | 250 U
Adenosine deaminase from calf spleen is a tissue-derived enzyme preparation that catalyzes the irreversible deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine. Supplied as a defined total activity, it is intended for use in biochemical assays, enzymology, and purine metabolism studies. Manufacturer-provided activity and handling information should be consulted before use.
- Derived from calf spleen tissue.
- Provided as 250 U total enzyme activity.
- Enzyme activity ≥15 U/mg (manufacturer specification).
- Unit definition: 1 μmol adenosine to inosine per minute at 25°C, pH 7.4.
- Suitable for biochemical assays and purine metabolism research.
- Store under conditions specified on the certificate of analysis.
Apexbio Technology LLC GTP Solution (100 mM) 1mL
GTP also known as Guanosine-5 -triphosphate can be utilized in various molecular biology applications such as in vitro transcription RNA amplification and siRNA synthesis Additionally GTP plays a critical regulatory role in signal transduction as a phosphate or pyrophosphate messenger it activates G-proteins which subsequently initiate protein kinase-mediated signaling cascades thus influencing cellular behaviors including cell proliferation and differentiation GTP also serves as a high-energy nucleotide precursor participating in enzymatic synthesis processes of DNA and RNA This product is prepared from GTP trisodium salt with purity 99% (HPLC) as a clear colorless aqueous solution at a concentration of 100 mM and pH (25 C) of 7 0 0 1 free from DNase and RNase contamination
Apexbio Technology LLC ATP Solution (100 mM) 250uL
ATP (Adenosine-5 -triphosphate) known as in Chinese is a fundamental component for energy transfer in biological systems ATP and its sodium salts can be utilized in numerous molecular biology applications such as kinase reactions in vitro transcription ligation reactions and phosphorylation assays This product is a colorless transparent aqueous solution prepared from ATP trisodium salt with a purity 99% (by HPLC) concentration of 100 mM pH (25 ) 7 0 0 1 and free of DNase RNase and phosphatase contamination